Age-Related Effects of Orthovanadate Nanoparticles Involve Activation of GSH-Dependent Antioxidant System in Liver Mitochondria.
Identifieur interne : 000092 ( Main/Exploration ); précédent : 000091; suivant : 000093Age-Related Effects of Orthovanadate Nanoparticles Involve Activation of GSH-Dependent Antioxidant System in Liver Mitochondria.
Auteurs : Yuri V. Nikitchenko [Ukraine] ; Vladimir K. Klochkov [Ukraine] ; Nataliya S. Kavok [Ukraine] ; Nina A. Karpenko [Ukraine] ; Svetlana L. Yefimova [Ukraine] ; Irina V. Nikitchenko [Ukraine] ; Anatoly I. Bozhkov [Ukraine]Source :
- Biological trace element research [ 1559-0720 ] ; 2020.
Abstract
Vanadium is an important ultra-trace element nowadays attracting attention with particular emphasis on medical application. But the therapeutic application of vanadium-based drugs is still questionable and restricted due to some toxic side effects. It was found that unique redox properties of vanadium in nanoform provided antioxidant activity and prevented oxidative disturbance in cells in vitro. Though, on the organism level, ambiguous effects of vanadium-based nanoparticles were observed. In this study, the age-related features of prooxidant/antioxidant balance in blood serum and liver mitochondrial and postmitochondrial fractions of 3 and 18-month-old Wistar male rats treated with orthovanadate nanoparticles (GdVO4/Eu3+, 8 × 25 nm) within 2 months have been investigated. Prooxidant potential-related indexes were the content of lipid hydroperoxides as well as aconitase activity. Activity of glutathione peroxidase, glutathione-S-transferase, glutaredoxin, glutathione reductase, glucose-6-phosphate dehydrogenase, and NADPH-dependent isocitrate dehydrogenase designated the tissue antioxidant potential. Based on the obtained values, the integral index of the prooxidant/antioxidant balance-the reliability coefficient (Kr) has been calculated. The data show that due to activation some chain links of GSH-dependent antioxidant system, GdVO4/Eu3+ nanoparticles increase the reliability of the prooxidant-antioxidant balance in tissues and especially in the liver mitochondria of old animals (Kr in mitochondria of young rats was 2.94, and in mitochondria of old ones-9.83 conventional units). Detected in vitro glutathione peroxidase-like activity of the GdVO4/Eu3+ nanoparticles is supposed to be among factors increasing the reliability of the system. So, for the first time, the beneficial effect of the long-term orthovanadate nanoparticle consumption in old males has been discovered.
DOI: 10.1007/s12011-020-02196-7
PubMed: 32447579
Affiliations:
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Nikitchenko</name><affiliation wicri:level="1"><nlm:affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000</wicri:regionArea><wicri:noRegion>61000</wicri:noRegion></affiliation></author><author><name sortKey="Klochkov, Vladimir K" sort="Klochkov, Vladimir K" uniqKey="Klochkov V" first="Vladimir K" last="Klochkov">Vladimir K. Klochkov</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072</wicri:regionArea><wicri:noRegion>61072</wicri:noRegion></affiliation></author><author><name sortKey="Kavok, Nataliya S" sort="Kavok, Nataliya S" uniqKey="Kavok N" first="Nataliya S" last="Kavok">Nataliya S. Kavok</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine. kavok@isma.kharkov.ua.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072</wicri:regionArea><wicri:noRegion>61072</wicri:noRegion></affiliation></author><author><name sortKey="Karpenko, Nina A" sort="Karpenko, Nina A" uniqKey="Karpenko N" first="Nina A" last="Karpenko">Nina A. Karpenko</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072</wicri:regionArea><wicri:noRegion>61072</wicri:noRegion></affiliation></author><author><name sortKey="Yefimova, Svetlana L" sort="Yefimova, Svetlana L" uniqKey="Yefimova S" first="Svetlana L" last="Yefimova">Svetlana L. Yefimova</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072</wicri:regionArea><wicri:noRegion>61072</wicri:noRegion></affiliation></author><author><name sortKey="Nikitchenko, Irina V" sort="Nikitchenko, Irina V" uniqKey="Nikitchenko I" first="Irina V" last="Nikitchenko">Irina V. Nikitchenko</name><affiliation wicri:level="1"><nlm:affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000</wicri:regionArea><wicri:noRegion>61000</wicri:noRegion></affiliation></author><author><name sortKey="Bozhkov, Anatoly I" sort="Bozhkov, Anatoly I" uniqKey="Bozhkov A" first="Anatoly I" last="Bozhkov">Anatoly I. Bozhkov</name><affiliation wicri:level="1"><nlm:affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000</wicri:regionArea><wicri:noRegion>61000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biological trace element research</title><idno type="eISSN">1559-0720</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vanadium is an important ultra-trace element nowadays attracting attention with particular emphasis on medical application. But the therapeutic application of vanadium-based drugs is still questionable and restricted due to some toxic side effects. It was found that unique redox properties of vanadium in nanoform provided antioxidant activity and prevented oxidative disturbance in cells in vitro. Though, on the organism level, ambiguous effects of vanadium-based nanoparticles were observed. In this study, the age-related features of prooxidant/antioxidant balance in blood serum and liver mitochondrial and postmitochondrial fractions of 3 and 18-month-old Wistar male rats treated with orthovanadate nanoparticles (GdVO<sub>4</sub>/Eu<sup>3+</sup>, 8 × 25 nm) within 2 months have been investigated. Prooxidant potential-related indexes were the content of lipid hydroperoxides as well as aconitase activity. Activity of glutathione peroxidase, glutathione-S-transferase, glutaredoxin, glutathione reductase, glucose-6-phosphate dehydrogenase, and NADPH-dependent isocitrate dehydrogenase designated the tissue antioxidant potential. Based on the obtained values, the integral index of the prooxidant/antioxidant balance-the reliability coefficient (Kr) has been calculated. The data show that due to activation some chain links of GSH-dependent antioxidant system, GdVO<sub>4</sub>/Eu<sup>3+</sup> nanoparticles increase the reliability of the prooxidant-antioxidant balance in tissues and especially in the liver mitochondria of old animals (Kr in mitochondria of young rats was 2.94, and in mitochondria of old ones-9.83 conventional units). Detected in vitro glutathione peroxidase-like activity of the GdVO<sub>4</sub>/Eu<sup>3+</sup> nanoparticles is supposed to be among factors increasing the reliability of the system. So, for the first time, the beneficial effect of the long-term orthovanadate nanoparticle consumption in old males has been discovered.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32447579</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1559-0720</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>May</Month><Day>24</Day></PubDate></JournalIssue><Title>Biological trace element research</Title><ISOAbbreviation>Biol Trace Elem Res</ISOAbbreviation></Journal><ArticleTitle>Age-Related Effects of Orthovanadate Nanoparticles Involve Activation of GSH-Dependent Antioxidant System in Liver Mitochondria.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12011-020-02196-7</ELocationID><Abstract><AbstractText>Vanadium is an important ultra-trace element nowadays attracting attention with particular emphasis on medical application. But the therapeutic application of vanadium-based drugs is still questionable and restricted due to some toxic side effects. It was found that unique redox properties of vanadium in nanoform provided antioxidant activity and prevented oxidative disturbance in cells in vitro. Though, on the organism level, ambiguous effects of vanadium-based nanoparticles were observed. In this study, the age-related features of prooxidant/antioxidant balance in blood serum and liver mitochondrial and postmitochondrial fractions of 3 and 18-month-old Wistar male rats treated with orthovanadate nanoparticles (GdVO<sub>4</sub>/Eu<sup>3+</sup>, 8 × 25 nm) within 2 months have been investigated. Prooxidant potential-related indexes were the content of lipid hydroperoxides as well as aconitase activity. Activity of glutathione peroxidase, glutathione-S-transferase, glutaredoxin, glutathione reductase, glucose-6-phosphate dehydrogenase, and NADPH-dependent isocitrate dehydrogenase designated the tissue antioxidant potential. Based on the obtained values, the integral index of the prooxidant/antioxidant balance-the reliability coefficient (Kr) has been calculated. The data show that due to activation some chain links of GSH-dependent antioxidant system, GdVO<sub>4</sub>/Eu<sup>3+</sup> nanoparticles increase the reliability of the prooxidant-antioxidant balance in tissues and especially in the liver mitochondria of old animals (Kr in mitochondria of young rats was 2.94, and in mitochondria of old ones-9.83 conventional units). Detected in vitro glutathione peroxidase-like activity of the GdVO<sub>4</sub>/Eu<sup>3+</sup> nanoparticles is supposed to be among factors increasing the reliability of the system. So, for the first time, the beneficial effect of the long-term orthovanadate nanoparticle consumption in old males has been discovered.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nikitchenko</LastName><ForeName>Yuri V</ForeName><Initials>YV</Initials><AffiliationInfo><Affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klochkov</LastName><ForeName>Vladimir K</ForeName><Initials>VK</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8080-1195</Identifier><AffiliationInfo><Affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kavok</LastName><ForeName>Nataliya S</ForeName><Initials>NS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2429-2832</Identifier><AffiliationInfo><Affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine. kavok@isma.kharkov.ua.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karpenko</LastName><ForeName>Nina A</ForeName><Initials>NA</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9709-3511</Identifier><AffiliationInfo><Affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yefimova</LastName><ForeName>Svetlana L</ForeName><Initials>SL</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2092-1950</Identifier><AffiliationInfo><Affiliation>Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nikitchenko</LastName><ForeName>Irina V</ForeName><Initials>IV</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5858-3382</Identifier><AffiliationInfo><Affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozhkov</LastName><ForeName>Anatoly I</ForeName><Initials>AI</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8418-5716</Identifier><AffiliationInfo><Affiliation>Biology Research Institute, Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61000, Ukraine.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>project № Ф64/29-2016</GrantID><Agency>the State Fund For Fundamental Research</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Trace Elem Res</MedlineTA><NlmUniqueID>7911509</NlmUniqueID><ISSNLinking>0163-4984</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Biol Trace Elem Res. 2020 Jun 5;:</RefSource><PMID Version="1">32504398</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">GdVO4/Eu3+ nanoparticles</Keyword><Keyword MajorTopicYN="N">Male rats</Keyword><Keyword MajorTopicYN="N">Mitochondria</Keyword><Keyword MajorTopicYN="N">Prooxidant/antioxidant balance</Keyword><Keyword MajorTopicYN="N">Vanadium</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32447579</ArticleId><ArticleId IdType="doi">10.1007/s12011-020-02196-7</ArticleId><ArticleId IdType="pii">10.1007/s12011-020-02196-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Ukraine</li></country></list><tree><country name="Ukraine"><noRegion><name sortKey="Nikitchenko, Yuri V" sort="Nikitchenko, Yuri V" uniqKey="Nikitchenko Y" first="Yuri V" last="Nikitchenko">Yuri V. Nikitchenko</name></noRegion><name sortKey="Bozhkov, Anatoly I" sort="Bozhkov, Anatoly I" uniqKey="Bozhkov A" first="Anatoly I" last="Bozhkov">Anatoly I. Bozhkov</name><name sortKey="Karpenko, Nina A" sort="Karpenko, Nina A" uniqKey="Karpenko N" first="Nina A" last="Karpenko">Nina A. Karpenko</name><name sortKey="Kavok, Nataliya S" sort="Kavok, Nataliya S" uniqKey="Kavok N" first="Nataliya S" last="Kavok">Nataliya S. Kavok</name><name sortKey="Klochkov, Vladimir K" sort="Klochkov, Vladimir K" uniqKey="Klochkov V" first="Vladimir K" last="Klochkov">Vladimir K. Klochkov</name><name sortKey="Nikitchenko, Irina V" sort="Nikitchenko, Irina V" uniqKey="Nikitchenko I" first="Irina V" last="Nikitchenko">Irina V. Nikitchenko</name><name sortKey="Yefimova, Svetlana L" sort="Yefimova, Svetlana L" uniqKey="Yefimova S" first="Svetlana L" last="Yefimova">Svetlana L. Yefimova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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